This website is for Canada residents only.
This website is for Canada residents only.

Investigational Therapy for Type 1 Diabetes

The UPWARD Study is looking for individuals living with type 1 diabetes (T1D) to participate in a study of an investigational cell-based therapy. The investigational therapy consists of cells designed to produce insulin contained within devices designed to protect the cells from the immune system. These investigational devices are implanted in the space behind the muscles of the abdominal wall. Researchers are studying the safety, tolerability, and effectiveness of the investigational therapy in adults with T1D and are looking to see if it could potentially reduce or eliminate the need for individuals with T1D to take insulin.

See if you may qualify

This clinical study is currently enrolling adults between the ages of 18 and 65 who have type 1 diabetes and require insulin via injections or pump to manage their diabetes. If you are interested in taking part in this clinical research study, please continue below and complete the questionnaire to determine if you are a good candidate and eligible for participation.

Learn more about this clinical study.

See If You May Qualify

Step 1 of 3

Please Read – Your Consent Is Required

The following pages contain some prescreening questions to determine whether you may be eligible to take part in the clinical research study. If you would like to participate in the prescreening, you will need to provide certain personal information such as your name, contact information, and postal code, as well as your answers to some health-related questions.

The sponsor of this study is accountable for your personal information. The sponsor has engaged Praxis (“we” or “us”) to assist with clinical trial recruitment for the study by collecting prescreening information for the study through this website. Your information will be used only to evaluate your eligibility for this study and, if you consent, to inform of potential Vertex research studies in the future.

The prescreener information you submit online will not be shared with the sponsor in any way that could identify you. The sponsor’s service provider, Praxis, which is located in the United States, will store this information as the operator of the website and will only share information in aggregate with the sponsor.

In the event that you are found potentially eligible for this study, you will have the option to provide contact information so we can connect you with myTomorrows, who is also a service provider to Vertex on this study, and a representative will contact you to do further screening. Based on the results of that screening, and with your permission, your information would be shared with a research site. In the event that you are not eligible for this study, you will have the option to provide contact information so that we (or another company hired to assist with this on behalf of the sponsor or a research site) can contact you if the eligibility criteria changes for this study or for future studies of the sponsor.

In either case, you do not have to provide contact information and can elect to have your personal information deleted instead. If you do not elect to delete the information, we will store it for as long as necessary to fulfill the purposes listed above, in accordance with applicable laws, or as indicated by your choice if you are electing for us to keep it to contact you in the future about this study or future studies of the sponsor.

You may withdraw your consent at any time and, upon withdrawal of your consent, we will promptly delete your personal information except to the extent required to comply with our legal obligations. For a fuller description of your privacy rights and the sponsor’s privacy practices, please see the sponsor’s Privacy Notice. You can read about your privacy rights under the heading “Privacy Preferences and Rights” and you may find contact information for the sponsor’s Data Protection Officer under the heading “How to Contact Us.” If you have a question or complaint, wish to withdraw consent, or exercise your other privacy rights (including access and correction), please contact Praxis at, as the sponsor will not receive any information about you from this website. The sponsor is Vertex Pharmaceuticals Incorporated.

Do you consent to submit your information? I confirm that I have read the information contained in this form and consent to the processing of my personal information for the purpose of determining my eligibility for this study, and, if I provide my consent and elect to provide my contact information, to be contacted about this study or future studies of the sponsor, all and as described above.

e.g., XXX XXX


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